Concomitant drugs with buprenorphine user deaths
نویسندگان
چکیده
Buprenorphine is abused in several countries notwithstanding its benefits as an analgesic and opioid agonist treatment medication. Benzodiazepines alcohol have previously been associated with buprenorphine toxicity. This study elucidates the role of emerging concomitant drugs different groups user deaths. All cases Finnish national post-mortem toxicology database from 2016–2019 which or norbuprenorphine was a laboratory finding any specimen age at death 15–64 years were investigated for cause manner death, concurrent drug findings, age, gender. There 792 deaths finding, implicated poisoning without other opioids 271 (34 %). In this group deaths, benzodiazepines found 94 % (clonazepam 53 %), illicit 63 %, gabapentinoids 50 (pregabalin 41 antidepressants 32 antipsychotics 28 cases; only three showed no benzodiazepines, alcohol, gabapentinoids. Polydrug use common regardless death. 15 to 24 years, drugs, more prevalent than 25–64 years. The unprecedentedly high obscures possible pharmacological risk factors that could be relevant prevention. Higher mortality younger suggests particularly unsafe patterns should addressed.
منابع مشابه
Six deaths linked to concomitant use of buprenorphine and benzodiazepines.
AIMS Buprenorphine at high dosage became available in 1996 for substitution treatment in France. This drug is considered particularly safe and has become widely available in general medical practice. We investigated the possible implication of a buprenorphine-benzodiazepine association in six deaths of known abusers. DESIGN Full investigation of cause of death was conducted for six drug abuse...
متن کاملBuprenorphine-associated deaths in Singapore.
Introduction Buprenorphine is a thebaine derivative that was developed in the 1970s for pain relief. It was approved for substitution therapy in France in 1996, and in the USA in 2002. In Singapore, sublingual buprenorphine (2 and 8 mg tablets) has been available since 2002 for the treatment of opioid addiction, under the brand name Subutex. It is registered as a prescription-only medicine, but...
متن کاملA survey of buprenorphine related deaths in Singapore.
Buprenorphine is available in Singapore as substitution treatment for opioid dependence since 2002. This study surveys buprenorphine related deaths in Singapore between September 2003 and December 2004. The aims are to establish the autopsy prevalence of buprenorphine related deaths and the demographical and toxicological profile of the cases. Toxicological screening was performed for all unnat...
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ژورنال
عنوان ژورنال: Drug and Alcohol Dependence
سال: 2021
ISSN: ['2772-7246']
DOI: https://doi.org/10.1016/j.drugalcdep.2020.108345